Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles
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چکیده
منابع مشابه
Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles.
A series of 1-methyl-4,5-diphenylimidazoles 6 with various patterns of m-halogen substitution at the 5-phenyl ring were tested for cytotoxicity in cancer and nonmalignant cell lines and for their capacity to prevent tube formation in HUVEC cultures. Unlike the monofluoro and difluoro derivatives 6a and 6e, the monobromo and diiodo analogs 6c and 6h were strongly cytotoxic and inhibited the poly...
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In the title compound, C(15)H(10)F(2)O(3)S, the 4-fluoro-phenyl ring makes a dihedral angle of 73.20 (4)° with the plane of the benzofuran fragment. The crystal structure is stabilized by aromatic π-π inter-actions between the furan and benzene rings of neighbouring mol-ecules [centroid-centroid distance = 3.805 (3) Å]. The crystal structure also exhibits weak inter-molecular C-H⋯O and C-H⋯F in...
متن کامل5-Fluoro-3-(4-fluorophenylsulfinyl)-2-methyl-1-benzofuran
In the title compound, C(15)H(10)F(2)O(2)S, the S=O and the 4-fluoro-phenyl groups are located on opposite sides of the plane of benzofuran ring system, and the 4-fluoro-phenyl ring is nearly perpendicular to the benzofuran plane with a dihedral angle of 89.93 (4)°. In the crystal structure, mol-ecules are linked by weak inter-molecular C-H⋯O hydrogen bonding and C-H⋯π inter-actions.
متن کامل3-(4-Bromophenylsulfinyl)-5-fluoro-2-methyl-1-benzofuran
There are two symmetry-independent mol-ecules, A and B, in the asymmetric unit of the title compound, C(15)H(10)BrFO(2)S. The dihedral angle formed by the 4-bromo-phenyl ring and the mean plane of the benzofuran fragment is 88.26 (6)° in mol-ecule A and 88.25 (6)° in mol-ecule B. In the crystal, mol-ecules are linked by weak inter-molecular C-H⋯F, C-H⋯O and C-H⋯π inter-actions. The crystal stru...
متن کامل5-Fluoro-2-methyl-3-(4-methylphenylsulfonyl)-1-benzofuran
In the title compound, C(16)H(13)FO(3)S, the 4-methyl-phenyl ring makes a dihedral angle of 76.04 (4)° with the mean plane of the benzofuran fragment. In the crystal, mol-ecules are linked by weak C-H⋯O hydrogen bonds, and by a slipped π-π inter-action between the furan and benzene rings of adjacent mol-ecules [centroid-centroid distance = 3.780 (2) Å, inter-planar distance = 3.475 (2) Å and sl...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2011
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2011.09.005